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Tyrphostin AG1433

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Chemical Structure| 168835-90-3 同义名 : SU1433;AG1433
CAS号 : 168835-90-3
货号 : A1226765
分子式 : C16H14N2O2
纯度 : 98%
分子量 : 266.295
MDL号 : MFCD03426524
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 60 mg/mL(225.31 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Tyrphostin AG1433 is a tyrosine kinase inhibitor. Tyrphostin AG1433 is also a selective PDGFRβ and VEGFR-2 (Flk-1/KDR) inhibitor, with IC50s of 5.0 μM and 9.3 μM, respectively. Tyrphostin AG1433 prevents angiogenesis[1][2][3 ][4].Tyrphostin AG1433 induces moderate cytotoxicity in GB8B cells in a concentration-dependent manner at concentrations ranging from 0.1-100 μM for 72 hours[1][2][3][4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.76mL

0.75mL

0.38mL

18.78mL

3.76mL

1.88mL

37.55mL

7.51mL

3.76mL
参考文献

[1]Serban F, et al. Silencing of epidermal growth factor, latrophilin and seven transmembrane domain-containing protein 1 (ELTD1) via siRNA-induced cell death in glioblastoma. J Immunoassay Immunochem. 2017;38(1):21-33.

[2]Strawn LM, et al. Flk-1 as a target for tumor growth inhibition. Cancer Res. 1996 Aug 1;56(15):3540-5.

[3]Kim TS, et al. The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress. Dis Model Mech. 2010 Nov-Dec;3(11-12):752-62.

[4]Kroll J, et al. The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells. J Biol Chem. 1997 Dec 19;272(51):32521-7.