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Omeprazole sulfide

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Chemical Structure| 73590-85-9 同义名 : 奥美拉唑硫醚 ;Ufiprazole;​OMEP sulfide;Pyrmetazole;OMZ sulfide;OMP sulfide
CAS号 : 73590-85-9
货号 : A122371
分子式 : C17H19N3O2S
纯度 : 99%
分子量 : 329.417
MDL号 : MFCD00869021
存储条件:

粉末 Keep in dark place,Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 105 mg/mL(318.75 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 Omeprazole sulfide is a metabolite of Omeprazole, which is a proton pump inhibitor.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.04mL

0.61mL

0.30mL

15.18mL

3.04mL

1.52mL

30.36mL

6.07mL

3.04mL

参考文献

[1]Jang HH, Ryu SH, et al. Regioselective C-H hydroxylation of omeprazole sulfide by Bacillus megaterium CYP102A1 to produce a human metabolite. Biotechnol Lett. 2017 Jan;39(1):105-112.

[2]Angus PW, Mihaly GW, et al. Oxygen dependence of omeprazole clearance and sulfone and sulfide metabolite formation in the isolated perfused rat liver. J Pharmacol Exp Ther. 1989 Sep;250(3):1043-7.