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Bisindolylmaleimide IV

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Chemical Structure| 119139-23-0 同义名 : 双吲哚马来酰亚胺IV ;Arcyriarubin A;BIM IV;Compound 5/1a
CAS号 : 119139-23-0
货号 : A122227
分子式 : C20H13N3O2
纯度 : 97%
分子量 : 327.336
MDL号 : MFCD00236432
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(366.6 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 The enzyme family protein kinase C (PKC) occupies a central role in the transduction of signals from a variety of mediators across the cell membrane. Inhibition of PKC may provide therapy for diseases such as rheumatoid arthritis (through inhibition of T-cell proliferation), cancer and AIDS (through inhibition of viral entry and viral gene expression). Bisindolylmaleimide IV is a potent PKC inhibitor, with IC50s ranging from 0.1 to 0.55 μM. It also inhibits PKA (cAMP-dependent protein kinase) with IC50s ranging from 3.1 to 11.8 μM[1]. Moreover, Bisindolylmaleimide IV has a good anti-HCMV (human cytomegaloviru) activity with an IC50 value of 0.2 μM[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.05mL

0.61mL

0.31mL

15.27mL

3.05mL

1.53mL

30.55mL

6.11mL

3.05mL
参考文献

[1]Davis PD, Hill CH, Lawton G, et al. Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides. J Med Chem. 1992;35(1):177-184

[2]Slater MJ, Cockerill S, Baxter R, et al. Indolocarbazoles: potent, selective inhibitors of human cytomegalovirus replication. Bioorg Med Chem. 1999;7(6):1067-1074