生物活性 | |||
---|---|---|---|
描述 | Lithium directly inhibits GSK3 by competitive binding for magnesium (Mg2+), disrupting the catalytic functioning of GSK3. Lithium also indirectly inhibits GSK3 by increasing serine phosphorylation, through P13K-mediated phosphorylation/activation of Akt. |
实验方案 | |||
---|---|---|---|
1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
23.59mL 4.72mL 2.36mL |
117.94mL 23.59mL 11.79mL |
235.88mL 47.18mL 23.59mL |
参考文献 |
---|