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TLX agonist 1

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Chemical Structure| 958323-31-4 同义名 : -
CAS号 : 958323-31-4
货号 : A1219206
分子式 : C23H26N4O
纯度 : 99%+
分子量 : 374.479
MDL号 : MFCD04123707
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 60 mg/mL(160.22 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Human nuclear receptors (NRs) are ligand-dependent transcriptional factors that control a myriad of biological and disease processes. Tailless (TLX) is an orphan NR expressed exclusively in the brain. It is engaged in transcriptional regulation under basal conditions and acts as a transcriptional repressor. TLX agonist 1 is an orphan nuclear receptor TLX modulator with EC50 value of 1±0.3 μM and Kd value of 650±100 nM. TLX agonist 1 potentiates TLX transcriptional repressive activity[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.67mL

0.53mL

0.27mL

13.35mL

2.67mL

1.34mL

26.70mL

5.34mL

2.67mL
参考文献

[1]Benod C, Villagomez R, Filgueira CS, et al. The human orphan nuclear receptor tailless (TLX, NR2E1) is druggable. PLoS One. 2014;9(6):e99440