Tempo

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Chemical Structure| 2564-83-2 同义名 : 2,2,6,6-四甲基哌啶氧化物
CAS号 : 2564-83-2
货号 : A121835
分子式 : C9H18NO
纯度 : 97%
分子量 : 156.245
MDL号 : MFCD00009599
存储条件:

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 105 mg/mL(672.02 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 100 mg/mL(640.02 mM),配合低频超声,并水浴加热至45℃助溶

动物实验配方:
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

6.40mL

1.28mL

0.64mL

32.00mL

6.40mL

3.20mL

64.00mL

12.80mL

6.40mL

参考文献

[1]Du K, et al. Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity. Arch Toxicol. 2017 Feb;91(2):761-773.

[2]Guo X, et al. Comparative Genotoxicity of TEMPO and 3 of Its Derivatives in Mouse Lymphoma Cells. Toxicol Sci. 2018 May 1;163(1):214-225.

[3] Lv H, et al. TEMPO catalyzed oxidative dehydrogenation of hydrazobenzenes to azobenzenes. Org Biomol Chem. 2020 Apr 22.

[4]Chen X, et al. Isocitrate dehydrogenase 2 contributes to radiation resistance of oesophageal squamous cell carcinoma via regulating mitochondrial function and ROS/pAKT signalling. Br J Cancer. 2020 May 5.