Gossypol (acetic acid)
产品说明书
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同义名 : | 乙酸棉子酚 ;(±)-Gossypol-acetic acid;BL-193 (acetic acid);AT101;Pogosin;Gossypol Acetic acid;Gossypol Acetate |
| CAS号 : | 12542-36-8 | |
| 货号 : | A1217964 | |
| 分子式 : | - | |
| 纯度 : | 98% (mix) | |
| 分子量 : | 0 | |
| MDL号 : | MFCD00058385 | |
| 存储条件： |
Pure form Inert atmosphere,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 25 mg/mL，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
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| 描述 | ossypol, extracted from cottonseeds and roots, is explored as an anticancer agent due to its natural presence and efficacy in clinical trials. The racemic form of Gossypol [(±)-Gossypol] is well tolerated in these studies and demonstrates specific binding to the Bcl-xL and Bcl-2 proteins with Ki values ranging from 0.5 to 0.6 μM and 0.2 to 0.3 mM, respectively. Among its enantiomers, (-)-Gossypol and (+)-Gossypol, the former shows significantly greater growth inhibition in UM-SCC-6 and UM-SCC-14A cell lines in MTT assays over six days. The racemic form [(±)-Gossypol] exhibits an intermediate growth inhibitory effect, most notably at higher doses (10 μM)[1]. | ||
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