JAMM protein inhibitor 2

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Chemical Structure| 848249-35-4 同义名 : -
CAS号 : 848249-35-4
货号 : A1217814
分子式 : C21H26N2O2
纯度 : 99%+
分子量 : 338.443
MDL号 : MFCD07316369
存储条件：

Pure form Sealed in dry,Room Temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 15 mg/mL(44.32 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 JAMM Protein Inhibitor 2, a powerful inhibitor of JAMM proteases, shows IC50 values of 10 μM for thrombin, 46 μM for Rpn11, and 89 μM for MMP2, and is suitable for anticancer research[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.95mL

0.59mL

0.30mL

14.77mL

2.95mL

1.48mL

29.55mL

5.91mL

2.95mL
参考文献

[1]Almahli H, Hadchity E, Jaballah MY, Daher R, Ghabbour HA, Kabil MM, Al-Shakliah NS, Eldehna WM. Development of novel synthesized phthalazinone-based PARP-1 inhibitors with apoptosis inducing mechanism in lung cancer. Bioorg Chem. 2018 Apr;77:443-456.