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PF-06446846

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Chemical Structure| 1632250-49-7 同义名 : -
CAS号 : 1632250-49-7
货号 : A1216864
分子式 : C22H20ClN7O
纯度 : 99%+
分子量 : 433.894
MDL号 : MFCD32182630
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 PF-06446846 is an orally active proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. PF-06446846 directly and selectively inhibits translation of PCSK9 by stalling 80S ribosomes near codon regions.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.30mL

0.46mL

0.23mL

11.52mL

2.30mL

1.15mL

23.05mL

4.61mL

2.30mL
参考文献

[1]Lintner NG, McClure KF, Petersen D, Londregan AT, Piotrowski DW, Wei L, Xiao J, Bolt M, Loria PM, Maguire B, Geoghegan KF, Huang A, Rolph T, Liras S, Doudna JA, Dullea RG, Cate JH. Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain. PLoS Biol. 2017 Mar 21;15(3):e2001882. doi: 10.1371/journal.pbio.2001882. Erratum in: PLoS Biol. 2018 Apr 17;16(4):e1002628. PMID: 28323820; PMCID: PMC5360235.