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PIN1 inhibitor API-1

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Chemical Structure| 680622-70-2 同义名 : -
CAS号 : 680622-70-2
货号 : A1216707
分子式 : C15H13F3N6O2
纯度 : 98%
分子量 : 366.298
MDL号 : N/A
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(682.5 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 PIN1 inhibitor API-1 is a specific Pin1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) inhibitor (API-1) with an IC50 of 72.3 nM. PIN1 inhibitor API-1 binds directly and specifically to the PIN1 inhibitor API-1 directly and specifically binds to the PPIase domain and effectively inhibits the cis-trans isomerisation activity of Pin1. PIN1 inhibitor API-1 preserves the active conformation of pXPO5 and restores its ability to transport pre-miRNA from the nucleus to the cytoplasm, thereby up-regulating the biogenesis of anticancer miRNAs, and inhibiting hepatocellular carcinoma both in vitro and in vivo[1].PIN1 inhibitor API-1 significantly inhibited the proliferation of SK-Hep-1, SNU-423 and Hep3B cells with low IC50 values (IC50=0.683-4.16 μM)[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.73mL

0.55mL

0.27mL

13.65mL

2.73mL

1.37mL

27.30mL

5.46mL

2.73mL
参考文献

[1]Pu W, et al. Targeting Pin1 by inhibitor API-1 regulates microRNA biogenesis and suppresses hepatocellularcarcinoma development. Hepatology. 2018 Aug;68(2):547-560.