IRAK4-IN-4

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Chemical Structure| 1850276-58-2 同义名 : -
CAS号 : 1850276-58-2
货号 : A1216693
分子式 : C22H16N2O2
纯度 : 99%+
分子量 : 340.375
MDL号 : N/A
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(73.45 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Interleukin-1 receptor-associated kinase 4 (IRAK4) is a kinase required for innate immune responses induced by Toll-like receptors and the interleukin-1 receptor family members. IRAK4-IN-4 (compound 15 in patent CN107163044A) is an IRAK4 inhibitor with an IC50 value of 2.8nM. Cyclic GMP-AMP synthase (cGAS) is a cytosolic protein that acts as an intracellular innate immune sensor that detects double-stranded DNA. IRAK4-IN-4 also exhibits inhibitory activity towards cGAS with an IC50 value of 2.1nM[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.94mL

0.59mL

0.29mL

14.69mL

2.94mL

1.47mL

29.38mL

5.88mL

2.94mL
参考文献

[1]One class has the naphthalene second dione compounds and its derivative of protease modification activities