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SBI-797812

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Chemical Structure| 2237268-08-3 同义名 : -
CAS号 : 2237268-08-3
货号 : A1216688
分子式 : C19H22N4O4S
纯度 : 99%+
分子量 : 402.467
MDL号 : MFCD32197237
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(621.17 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 SBI-797812 functions as an orally active activator of nicotinamide phosphoribosyltransferase (NAMPT). It induces a shift in NAMPT activity towards NMN formation, enhances NAMPT's affinity for ATP, stabilizes phosphorylated NAMPT, facilitates the consumption of pyrophosphate by-product, and attenuates feedback inhibition by NAD+. SBI-797812 leads to elevated intracellular nicotinamide mononucleotide (NMN) levels and increased liver NAD+ concentrations in mice[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.48mL

0.50mL

0.25mL

12.42mL

2.48mL

1.24mL

24.85mL

4.97mL

2.48mL
参考文献

[1]Gardell SJ , et al. Boosting NAD+ with a small molecule that activates NAMPT. Nat Commun. 2019 Jul 19;10(1):3241.

[2]Khaidizar FD, et al. Nicotinamide Phosphoribosyltransferase as a Key Molecule of the Aging/Senescence Process. Int J Mol Sci. 2021 Apr 2;22(7):3709.