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BCI

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Chemical Structure| 1245792-51-1 同义名 : (E)-BCI
CAS号 : 1245792-51-1
货号 : A1216682
分子式 : C22H23NO
纯度 : 99%+
分子量 : 317.424
MDL号 : MFCD20232928
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(378.04 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 BCI is a DUSP6 inhibitor. BCI has anti-inflammatory activity and reduces the production of reactive oxygen species (ROS). BCI can be used in inflammatory disease studies[1][2].At a concentration of 100 ng/mL for 24 h, BCI down-regulated DUSP6 expression in RAW264.7 macrophages. At a concentration of 1 nM for 24 h, BCI inhibited the expression of IL-1β and IL-6 in lipid LPS-activated macrophages. At a concentration of 4 nM for 24 h, BCI reduced ROS production and activated the Nrf2 pathway in LPS-activated macrophages[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.15mL

0.63mL

0.32mL

15.75mL

3.15mL

1.58mL

31.50mL

6.30mL

3.15mL
参考文献

[1]Korotchenko VN, et al. In vivo structure-activity relationship studies support allosteric targeting of a dual specificity phosphatase. Chembiochem. 2014 Jul 7;15(10):1436-45.

[2]Zhang F, et al. DUSP6 Inhibitor (E/Z)-BCI Hydrochloride Attenuates Lipopolysaccharide-Induced Inflammatory Responses in Murine Macrophage Cells via Activating the Nrf2 Signaling Axis and Inhibiting the NF-κB Pathway. Inflammation. 2019 Apr;42(2):672-681.