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Thalidomide-5-COOH

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Chemical Structure| 1216805-11-6 同义名 : -
CAS号 : 1216805-11-6
货号 : A1215373
分子式 : C14H10N2O6
纯度 : 98%
分子量 : 302.239
MDL号 : MFCD32063447
存储条件:

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 120 mg/mL(397.04 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 Thalidomide-5-COOH is a Thalidomide-based cereblon ligand employed for recruiting CRBN protein. It can be linked to another protein ligand using a linker to create PROTACs [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.31mL

0.66mL

0.33mL

16.54mL

3.31mL

1.65mL

33.09mL

6.62mL

3.31mL

参考文献

[1]Liu K, et, al. Design and biological characterization of hybrid compounds of curcumin and thalidomide for multiple myeloma. Org Biomol Chem. 2013 Aug 7;11(29):4757-63.