产品说明书

BMS-1

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Chemical Structure| 1675201-83-8 同义名 : Programmed Cell Death 1/Programmed Cell Death-Ligand 1 Inhibitor 1;PD-1/PD-L1 inhibitor 1;PD1-PDL1-IN1;PD1-PDL1 inhibitor 1
CAS号 : 1675201-83-8
货号 : A121482
分子式 : C29H33NO5
纯度 : 99%+
分子量 : 475.576
MDL号 : MFCD28978741
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 6 mg/mL(12.62 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

DMF: 5 mg/mL(10.51 mM)，配合低频超声助溶
动物实验配方：

IP 5% DMSO + water 0.1 mg/mL clear

生物活性
靶点

  • PD-1/PD-L1 interaction

    PD-1/PD-L1 interaction, IC50:0.006 μM
描述 BMS-1 is a selective inhibitor targeting the interaction between PD-1 and PD-L1, with an inhibitory concentration range (IC50) spanning from 6 to 100 nM[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.10mL

0.42mL

0.21mL

10.51mL

2.10mL

1.05mL

21.03mL

4.21mL

2.10mL
参考文献

[1]Zhao Y, et al. Depression Promotes Hepatocellular Carcinoma Progression through a Glucocorticoids Mediated Up-Regulation of PD-1 Expression in Tumor infiltrating NK Cells. Carcinogenesis. 2019 Feb 4.

[2]Li K, et al. Development of small-molecule immune checkpoint inhibitors of PD-1/PD-L1 as a new therapeutic strategy for tumour immunotherapy. J Drug Target. 2019 Mar;27(3):244-256.

[3]Zhang H, et al. Utilizing VEGF165b mutant as an effective immunization adjunct to augment antitumor immune response. Vaccine. 2019 Apr 3;37(15):2090-2098.