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RPW-24

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Chemical Structure| 1001625-82-6 同义名 : -
CAS号 : 1001625-82-6
货号 : A1211320
分子式 : C15H13ClN4
纯度 : 99%+
分子量 : 284.743
MDL号 : MFCD05840188
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 RPW-24, protects C. elegans from bacterial infection by stimulating the host immune response of the nematode. RPW-24 strongly stimulates the innate immune response of nematodes by giving them a survival advantage in the process of bacterial infection. RPW-24 promotes resistance to Pseudomonas aeruginosa infection by inducing the transcription of a remarkably small number of C. elegans genes (∼1.3% of all genes) in a manner that partially depends on the evolutionarily-conserved p38 MAP kinase pathway and the transcription factor ATF-7[1]. RPW-24 is a xenobiotic toxin to C. elegans. RPW-24 caused a dose dependent reduction of nematode lifespan on nonpathogenic food and delayed development of animals that were exposed starting at the first larval stage[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.51mL

0.70mL

0.35mL

17.56mL

3.51mL

1.76mL

35.12mL

7.02mL

3.51mL
参考文献

[1]Pukkila-Worley R, Feinbaum R, Kirienko NV, Larkins-Ford J, Conery AL, Ausubel FM. Stimulation of host immune defenses by a small molecule protects C. elegans from bacterial infection. PLoS Genet. 2012;8(6):e1002733

[2]Pukkila-Worley R, Feinbaum RL, McEwan DL, Conery AL, Ausubel FM. The evolutionarily conserved mediator subunit MDT-15/MED15 links protective innate immune responses and xenobiotic detoxification. PLoS Pathog. 2014;10(5):e1004143.