产品说明书

Clovamide

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Chemical Structure| 53755-02-5 同义名 : trans-Clovamide;N-[3',4'-Dihydroxy-(E)-cinnamoyl]-3-hydroxy-L-tyrosine;N-trans-Caffeoy-L-dopa;N-trans-Caffeoyl-L-DOPA
CAS号 : 53755-02-5
货号 : A1210988
分子式 : C18H17NO7
纯度 : 97%
分子量 : 359.33
MDL号 : MFCD18252514
存储条件:

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 120 mg/mL(333.95 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 Clovamide, a natural phenolic compound, is a potent antioxidant and acts as an excellent scavenger of ROS and oxygen radicals. Clovamide also has anti-inflammatory and neuroprotective properties[1][2].Clovamide is also an anti-microbial agent with activity against the human pathogens influenza A subtype H5N1, Trypanosoma evansi and Helicobacter pylori[3].Clovamide was able to protect against neuronal damage in three in vitro models of neuronal death, including oxidative stress, excitotoxicity and OGD/reoxygenation. In SH-SY5Y human neuroblastoma cells, Clovamide significantly protected against cell death at concentrations in the range of 10-100 µM with an EC50 value of 3.6 µM. Clovamide also significantly enhanced PPARγ expression[2].Clovamide inhibits the growth of three pathogens of the cacao in the genus Phytophthora, is a substrate for cocoa polyphenol oxidase and a contributor to enzymatic browning. Clovamide inhibits proteases and pectinases in vitro[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.78mL

0.56mL

0.28mL

13.91mL

2.78mL

1.39mL

27.83mL

5.57mL

2.78mL