生物活性 | |||
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描述 | Clovamide, a natural phenolic compound, is a potent antioxidant and acts as an excellent scavenger of ROS and oxygen radicals. Clovamide also has anti-inflammatory and neuroprotective properties[1][2].Clovamide is also an anti-microbial agent with activity against the human pathogens influenza A subtype H5N1, Trypanosoma evansi and Helicobacter pylori[3].Clovamide was able to protect against neuronal damage in three in vitro models of neuronal death, including oxidative stress, excitotoxicity and OGD/reoxygenation. In SH-SY5Y human neuroblastoma cells, Clovamide significantly protected against cell death at concentrations in the range of 10-100 µM with an EC50 value of 3.6 µM. Clovamide also significantly enhanced PPARγ expression[2].Clovamide inhibits the growth of three pathogens of the cacao in the genus Phytophthora, is a substrate for cocoa polyphenol oxidase and a contributor to enzymatic browning. Clovamide inhibits proteases and pectinases in vitro[3]. |
实验方案 | |||
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1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.78mL 0.56mL 0.28mL |
13.91mL 2.78mL 1.39mL |
27.83mL 5.57mL 2.78mL |