CAN508
产品说明书
 |
同义名 : | CAY10574 |
| CAS号 : | 140651-18-9 | |
| 货号 : | A1210582 | |
| 分子式 : | C9H10N6O | |
| 纯度 : | 97% | |
| 分子量 : | 218.215 | |
| MDL号 : | MFCD09262258 | |
| 存储条件： |
Pure form Keep in dark place,Inert atmosphere,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 250 mg/mL(1145.66 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
|
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | CAN508 is a strong, ATP-competitive inhibitor of CDK9/cyclin T1, with an IC50 of 0.35 μM, showing 38 times more selectivity for CDK9/cyclin T compared to other CDK/cyclin complexes, and has demonstrated antitumor activity[1]. It decreases the proportion of S-phase cells in the HT-29 cancer cell line in antiproliferation assays[1]. At concentrations of 20-40 μM over 72 hours, CAN508 notably reduces cell proliferation in a dose-dependent manner across three esophageal adenocarcinoma cell lines (SKGT4, OE33, and FLO-1), with IC50 values ranging from 34.99 to 91.09 μM. Additionally, at 40 μM for 72 hours, CAN508 increases apoptosis in these esophageal adenocarcinoma cells[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
4.58mL 0.92mL 0.46mL |
22.91mL 4.58mL 2.29mL |
45.83mL 9.17mL 4.58mL |
| 参考文献 |
|---|