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4-MMPB

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Chemical Structure| 928853-86-5 同义名 : 15-Lipoxygenase Inhibitor 1;15-LO Inhibitor 1
CAS号 : 928853-86-5
货号 : A1210371
分子式 : C16H19N5S
纯度 : 99%+
分子量 : 313.42
MDL号 : -
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 6 mg/mL(19.14 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 4-MMPB is a selective inhibitor of 15-lipoxygenase with an IC50 value of 18 μM. 4-MMPB has an IC50 of 19.5 μM and 19.1 μM for soybean 15-lipoxygenase (SLO) and human 15-lipoxygenase-1 (15-LOX-1), respectively[1][2][3][4].The IC50 value of 4-MMPB for DPPH bleaching was 69.6 μM[2].At a concentration of 41.48 µM for 72 hours, 4-MMPB induced apoptosis and DNA damage in PC-3 cells[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.19mL

0.64mL

0.32mL

15.95mL

3.19mL

1.60mL

31.91mL

6.38mL

3.19mL
参考文献

[1]M Bakavoli, et al. Design and synthesis of pyrimido[4,5-b][1,4]benzothiazine derivatives, as potent 15-lipoxygenase inhibitors. Bioorg Med Chem. 2007 Mar 1;15(5):2120-6.

[2]Mohsen Nikpour, et al. Synthesis of new series of pyrimido[4,5-b][1,4] benzothiazines as 15-lipoxygenase inhibitors and study of their inhibitory mechanism. 2013, 22(10), 5036-5043.

[3]Seyed Jamal Alavi, et al. A novel class of human 15-LOX-1 inhibitors based on 3-hydroxycoumarin. Chem Biol Drug Des. 2018 Jun;91(6):1125-1132.

[4]Saffiyeh Saboormaleki, et al. 7-Farnesyloxycoumarin Exerts Anti-cancer Effects on a Prostate Cancer Cell Line by 15-LOX-1 Inhibition. Arch Iran Med. 2018 Jun 1;21(6):251-259.