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Boc-Asp(OMe)-fluoromethyl ketone

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Chemical Structure| 187389-53-3 同义名 : Boc-Asp(OMe)-FMK;Boc-D-FMK;Boc-D(OMe)-FMK;Boc-D-Fluoromethyl Ketone;BAF
CAS号 : 187389-53-3
货号 : A1209725
分子式 : C11H18FNO5
纯度 : 90%
分子量 : 263.263
MDL号 : MFCD03453073
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(398.84 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Boc-Asp(OMe)-fluoromethyl ketone is a caspase pan-inhibitor that inhibits Fas-mediated phagocytosis and oxidative rupture inhibition without affecting the chemotactic activity of IL-8 [1][2].Boc-Asp(OMe)-fluoromethyl ketone at 100 μM for 30 min prevented Fas-induced and spontaneous apoptosis in polymorphonuclear leukocytes[1].Boc-Asp(OMe)-fluoromethyl ketone at a concentration of 20 μM for 5 hours significantly increased LDH release in J774.1/JA-4 cells[2] .
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.80mL

0.76mL

0.38mL

18.99mL

3.80mL

1.90mL

37.98mL

7.60mL

3.80mL
参考文献

[1]Paunel-Görgülü A, et al. Stimulation of Fas signaling down-regulates activity of neutrophils from major trauma patients with SIRS. Immunobiology. 2011;216(3):334-342.

[2]Koike A, et al. Pan-caspase inhibitors induce necroptosis via ROS-mediated activation of mixed lineage kinase domain-like protein and p38 in classically activated macrophages. Exp Cell Res. 2019;380(2):171-179.