PTP Inhibitor IV

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Chemical Structure| 329317-98-8 同义名 : Protein Tyrosine Phosphatase Inhibitor IV
CAS号 : 329317-98-8
货号 : A1209660
分子式 : C26H26F6N2O4S2
纯度 : 97%
分子量 : 608.616
MDL号 : MFCD06660111
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(410.77 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 PTP Inhibitor IV is a protein tyrosine phosphatase (PTP) inhibitor that competitively inhibits DUSP14 phosphatase activity by binding to the catalytic site with an IC50 value of 5.21 μM[1].PTP Inhibitor IV inhibits SHP-2, PTP1B, PTP-ε, PTP Meg-2, PTP-σ, PTP-β, and PTP-μ with IC50 values of 1.8 μM, 2.5 μM, 8.4 μM, 13 μM, 20 μM, 6.4 μM, and 6.7 μM, respectively[2].At concentrations less than 100 μM, acting for 3 hours, PTP Inhibitor IV effectively and specifically inhibits DUSP14-mediated JNK dephosphorylation[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.64mL

0.33mL

0.16mL

8.22mL

1.64mL

0.82mL

16.43mL

3.29mL

1.64mL
参考文献

[1]Jae Eun Park, et al. PTP inhibitor IV protects JNK kinase activity by inhibiting dual-specificity phosphatase 14 (DUSP14). Biochem Biophys Res Commun. 2009 Oct 2;387(4):795-9.

[2]Ping Huang, et al. Structure-based design and discovery of novel inhibitors of protein tyrosine phosphatases. Bioorg Med Chem. 2003 Apr 17;11(8):1835-49.