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Dilazep 2HCl

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Chemical Structure| 20153-98-4 同义名 : Dilazep (hydrochloride);Dilazep dihydrochloride;K-285;ASTA C 4898;AS 05;Dilazep HCl
CAS号 : 20153-98-4
货号 : A1209644
分子式 : C31H46Cl2N2O10
纯度 : 97%
分子量 : 677.61
MDL号 : MFCD00133267
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 65 mg/mL(95.93 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(147.58 mM)
动物实验配方：
生物活性
描述 Dilazep dihydrochloride acts as an adenosine uptake inhibitor. It promotes cerebral and coronary vasodilation by amplifying adenosine's effects. Additionally, Dilazep dihydrochloride prevents ischemic injury, platelet clumping, and the cellular uptake of nucleosides[1][2]. In vitro studies have thoroughly examined the uptake mechanism, revealing that Dilazep, NBI, and Dipyridamole can all inhibit adenosine absorption in various cell types. Among these, Dilazep and NBI demonstrate nearly ten-fold greater potency compared to Dipyridamole. Moreover, Dilazep is unique in its water solubility, eliminating the need for any solubility-enhancing organic solvents when preparing its aqueous solution[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.48mL

0.30mL

0.15mL

7.38mL

1.48mL

0.74mL

14.76mL

2.95mL

1.48mL
参考文献

[1]Zhang Y, et al. Dilazep potentiation of adenosine-mediated superior mesenteric arterial vasodilation. J Pharmacol Exp Ther. 1991 Sep;258(3):767-71.

[2]Kawagoe J, et al. Effect of dilazep dihydrochloride against ischemia and reperfusion-induced disruption of blood-brain barrier in rats: a quantitative study. Naunyn Schmiedebergs Arch Pharmacol. 1992 Apr;345(4):485-8.