Antalarmin HCl

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Chemical Structure| 220953-69-5 同义名 : Antalarmin (hydrochloride);Antalarmin hydrochloride
CAS号 : 220953-69-5
货号 : A1209598
分子式 : C24H35ClN4
纯度 : 97%
分子量 : 415.014
MDL号 : MFCD05664721
存储条件：

Pure form Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 12 mg/mL(28.91 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

无水乙醇: 12 mg/mL(28.91 mM)，配合低频超声，并水浴加热至45℃助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇

DMF: 20 mg/mL(48.19 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Antalarmin HCl is a non-peptide CRHR1 antagonist with a Ki value of 1 nM. Antalarmin HCl inhibits CRH-induced ACTH secretion, and blocks CRH- and novel-object-induced anxiety-like behaviours in animal model. Antalarmin HCl produces an anti-inflammatory effect in a model of arthritis and inhibits the pressure-induced gastric ulcers associated with irritable bowel syndrome[1][2][3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.41mL

0.48mL

0.24mL

12.05mL

2.41mL

1.20mL

24.10mL

4.82mL

2.41mL
参考文献

[1]Webster EL, et al. In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation. Endocrinology. 1996 Dec;137(12):5747-50. doi: 10.1210/endo.137.12.8940412.

[2]Zorrilla EP, et al. Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat. Brain Res. 2002 Oct 18;952(2):188-99.

[3]Deak T, et al. The impact of the nonpeptide corticotropin-releasing hormone antagonist antalarmin on behavioral and endocrine responses to stress. Endocrinology. 1999 Jan;140(1):79-86.