产品说明书

A-286982

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Chemical Structure| 280749-17-9 同义名 : -
CAS号 : 280749-17-9
货号 : A1209591
分子式 : C24H27N3O4S
纯度 : 97%
分子量 : 453.554
MDL号 : MFCD19690958
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(110.24 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 A-286982 is a potent and allosteric inhibitor of LFA-1/ICAM-1 interactions, with IC50s of 44 nM in the LFA-1/ICAM-1 binding assay and 35 nM in the LFA-1-mediated cell adhesion assay[1][2].A-286982 binds to the I structural domain allosteric site (IDAS), as evidenced by the fact that this isoform passes through the A-286982 binding site during delivery from the β-subunit I-like structural domain to the α-subunit ICAM binding site[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.20mL

0.44mL

0.22mL

11.02mL

2.20mL

1.10mL

22.05mL

4.41mL

2.20mL
参考文献

[1]G Liu, et al. Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 1. Identification of an additional binding pocket based on an anilino diaryl sulfide lead. J Me

[2]Susan M Keating, et al. Competition between intercellular adhesion molecule-1 and a small-molecule antagonist for a common binding site on the alphal subunit of lymphocyte function-associated antigen-1. Protein Sci. 2006 Feb;15(2):290-303.