产品说明书
CCG-100602
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同义名 : | - |
| CAS号 : | 1207113-88-9 | |
| 货号 : | A1209577 | |
| 分子式 : | C21H17ClF6N2O2 | |
| 纯度 : | 99%+ | |
| 分子量 : | 478.81 | |
| MDL号 : | - | |
| 存储条件： |
粉末 Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(219.29 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | CCG-100602 is a specific inhibitor of MRTF-A/SRF signalling. CCG-100602 specifically blocks MRTF-A nuclear localisation, thereby inhibiting the fibrotic transcription factor SRF and blocking the expression of MRTF-A/SRF activated genes[1][2].At concentrations of 3-30 μM, CCG-100602 reduces the number of adherent hASC cells[2].At concentrations of 5-40 μM, CCG-100602 reduced TGF-β1 (5 mg/ml) induced COL1A1, FN1 and ACTA2 transcription in a dose-dependent manner, and also reduced TGF-β1 induced protein expression of ECM and α-SMA[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.09mL 0.42mL 0.21mL |
10.44mL 2.09mL 1.04mL |
20.89mL 4.18mL 2.09mL |
| 参考文献 |
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