exo-IWR-1

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Chemical Structure| 1127442-87-8 同义名 : IWR-1-exo
CAS号 : 1127442-87-8
货号 : A1209516
分子式 : C25H19N3O3
纯度 : 98%+
分子量 : 409.437
MDL号 : MFCD18086912
存储条件：

Pure form Inert atmosphere,Room Temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 2 mg/mL(4.88 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 exo-IWR-1 is an inactive stereoisomer of Endo-IWR-1 and is a negative control for IWR-1. IWR-1 is a tankyrase inhibitor that inhibits the Wnt/β-catenin signalling pathway[1][2].At a concentration of 10 μM, exo-IWR-1 does not affect the number of 293T cells infected with bunyaviruses[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.44mL

0.49mL

0.24mL

12.21mL

2.44mL

1.22mL

24.42mL

4.88mL

2.44mL
参考文献

[1]Brooke Hamion, et al. Genome-wide RNA Interference Screen Identifies Novel Drug Targets for Rift Valley Fever Virus That Minimi the Potential for Drug Resistance.

[2]Brooke Harmon, et al. A Genome-Wide RNA Interference Screen Identifies a Role for Wnt/β-Catenin Signaling during Rift Valley Fever Virus Infection. J Virol. 2016 Jul 27;90(16):7084-7097.