产品说明书

MLS-573151

Print
Chemical Structure| 10179-57-4 同义名 : MLS000573151
CAS号 : 10179-57-4
货号 : A1209427
分子式 : C21H19N3O2S
纯度 : 99%+
分子量 : 377.459
MDL号 : MFCD00358662
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(278.18 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 MLS-573151 is a selective inhibitor of the GTPase Cdc42 with an EC50 value of 2 μM. MLS-573151 is inactive against other GTPase family members, such as Rab2, Rab7, H-Ras, Rac1, Rac 2, and the wild-type of RhoA. MLS-573151 acts by blocking GTP binding to Cdc42[1][2].MLS-573151 inhibits phagocytosis of granulocytes at a concentration of 50 μM for 15 minutes[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.65mL

0.53mL

0.26mL

13.25mL

2.65mL

1.32mL

26.49mL

5.30mL

2.65mL
参考文献

[1]Zurab Surviladze, et al. Identification of a small GTPase inhibitor using a high-throughput flow cytometry bead-based multiplex assay. J Biomol Screen. 2010 Jan;15(1):10-20.

[2]Fan Mao, et al. Transcriptomic Evidence Reveals the Molecular Basis for Functional Differentiation of Hemocytes in a Marine Invertebrate, Crassostrea gigas. Front Immunol. 2020 May 27;11:911.