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JGB1741

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Chemical Structure| 1256375-38-8 同义名 : ILS-JGB-1741
CAS号 : 1256375-38-8
货号 : A1209424
分子式 : C27H24N2O2S
纯度 : 97%
分子量 : 440.557
MDL号 : MFCD02303516
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 4 mg/mL(9.08 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 JGB1741, also known as ILS-JGB-1741, is a potent, specific inhibitor of SIRT1 activity with an IC50 of 15 μM. JGB1741 is a weak inhibitor of both SIRT2 and SIRT3, with IC50s greater than 100 μM. JGB1741 enhances the level of acetylated p53, leading to p53-mediated apoptosis, and regulates Bax/Bcl2 ratio. JGB1741 increased the level of acetylated p53, led to p53-mediated apoptosis, and regulated Bax/Bcl2 ratio, cytochrome c release and PARP fragmentation. JGB1741 inhibited the proliferation of MDA-MB 231 cells at a concentration of less than 10 μM for 24 h. JGB1741 caused cell cycle arrest in G1 phase, increased the proportion of cells entering sub-G0/G1 phase, and induced apoptosis of MDA-MB 231 cells. At a concentration range of 0.01-1 μM for 24 hours of action, JGB1741 resulted in increased levels of global acetylation of H3K9, p53 expression and acetylated p53K382[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.27mL

0.45mL

0.23mL

11.35mL

2.27mL

1.13mL

22.70mL

4.54mL

2.27mL
参考文献

[1]Arunasree M Kalle, et al. Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells. Biochem Biophys Res Commun. 2010 Oct 8;401(1):13-9.