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Preladenant

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Chemical Structure| 377727-87-2 同义名 : SCH-420814;MK-3814;Privadenant
CAS号 : 377727-87-2
货号 : A120930
分子式 : C25H29N9O3
纯度 : 99%+
分子量 : 503.556
MDL号 : MFCD17167056
存储条件：

粉末 Keep in dark place,Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 4 mg/mL(7.94 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Preladenant is a potent competitive antagonist of the human A2A receptor (Ki=1.1 nM) and has > 1000-fold selectivity over all other adenosine receptors.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00406029 Parkinson Disease ... 展开 >> Movement Disorders Central Nervous System Diseases Neurodegenerative Diseases Brain Diseases 收起 << Phase 2 Completed - -
NCT01155466 Parkinson Disease Phase 3 Completed - -
NCT01215227 Parkinson Disease ... 展开 >> Idiopathic Parkinson Disease 收起 << Phase 3 Terminated - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.99mL

0.40mL

0.20mL

9.93mL

1.99mL

0.99mL

19.86mL

3.97mL

1.99mL
参考文献

[1]Hodgson RA, Bedard PJ, et al. Preladenant, a selective A(2A) receptor antagonist, is active in primate models of movement disorders. Exp Neurol. 2010 Oct;225(2):384-90.

[2]Hodgson RA, Bertorelli R, et al. Characterization of the potent and highly selective A2A receptor antagonists preladenant and SCH 412348 [7-[2-[4-2,4-difluorophenyl] -1-piperazinyl] ethyl] -2-(2-furanyl)-7H-pyrazolo[4,3-e ] [1,2,4] triazolo[1,5-c] pyrimidin-5-amine] in rodent models of movement disorders and depression. J Pharmacol Exp Ther. 2009 Jul;330(1):294-303.