产品说明书

AT-007

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Chemical Structure| 2170729-29-8 同义名 : -
CAS号 : 2170729-29-8
货号 : A1207401
分子式 : C17H10F3N3O3S2
纯度 : 99%+
分子量 : 425.405
MDL号 : N/A
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 35 mg/mL(82.27 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Aldose Reductase (AR) is responsible for formation of a toxic metabolite of galactose, called galactitol, which has been shown to be responsible for many of the long-term complications in Galactosemia[1]. AT-007 is an orally active central nervous system (CNS) penetrant AR inhibitor for treatment of Galactosemia with an IC50 value of 100 pM. AT-007 reduces toxic galactitol levels and prevents disease complications in an animal model of Galactosemia[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.35mL

0.47mL

0.24mL

11.75mL

2.35mL

1.18mL

23.51mL

4.70mL

2.35mL