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Fluorofenidone

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Chemical Structure| 848353-85-5 同义名 : AKF-PD
CAS号 : 848353-85-5
货号 : A1207399
分子式 : C12H10FNO
纯度 : 99%+
分子量 : 203.212
MDL号 : MFCD29088959
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 135 mg/mL(664.33 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Oxidative stress plays an important role in the progression of renal interstitial fibrosis. The nicotinamide adeninedinucleotide phosphate (NADPH) oxidase (Nox) family is considered one of the major sources of reactive oxygen species (ROS)[1]. Fluorofenidone is an effective and novel antifibrotic agent with an IC50 value of 4.18 mM[2]. Fluorofenidone treatment significantly attenuated tubulo-interstitial injury, ECM deposition and oxidative stress in fibrotic rat kidneys. In addition, Fluorofenidone inhibited the expression of ROS, Collagen I (1a), Nox2, p-Akt in Ang II-stimulated NRK-52E cells. Fluorofenidone attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and ECM deposition via the PI3K/Akt signalling pathway, suggesting Fluorofenidone is a potential and novel therapeutic agent against renal fibrosis[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.92mL

0.98mL

0.49mL

24.60mL

4.92mL

2.46mL

49.21mL

9.84mL

4.92mL
参考文献

[1]Qin J, Xie YY, Huang L, Yuan QJ, Mei WJ, Yuan XN, Hu GY, Cheng GJ, Tao LJ, Peng ZZ. Fluorofenidone inhibits nicotinamide adeninedinucleotide phosphate oxidase via PI3K/Akt pathway in the pathogenesis of renal interstitial fibrosis. Nephrology (Carlton). 2013 Oct;18(10):690-9. doi: 10.1111/nep.12128. PMID: 23841831.

[2]Lou Q, Meng X, Lao Z, Xuan L, Bai J, Hou Q, Hu G, Luo R, Tao L, Li Z. Design, synthesis and antifibrotic activities of carbohydrate-modified 1-(substituted aryl)-5-trifluoromethyl-2(1H) pyridones. Molecules. 2012 Jan 17;17(1):884-96. doi: 10.3390/molecules17010884. PMID: 22252504; PMCID: PMC6269014.