产品说明书

Liproxstatin-1

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Chemical Structure| 950455-15-9 同义名 : -
CAS号 : 950455-15-9
货号 : A120662
分子式 : C19H21ClN4
纯度 : 99%+
分子量 : 340.85
MDL号 : MFCD14948691
存储条件：

粉末 Keep in dark place,Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(88.02 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：

IP 2% DMSO+2% Tween80+30% PEG300+water 10 mg/mL clear

PO 0.5% CMC-Na 40 mg/mL suspension

生物活性
靶点

  • Ferroptosis

    ferroptosis, IC50:22 nM
描述 Liproxstatin-1 acts as a powerful inhibitor of ferroptosis, blocking ferroptotic cell death with an IC50 value of 22 nM[1].
作用机制 Liproxstatin-1 is a spiroquinoxalinamine derivative that suppresses ferroptosis via lipid peroxide scavenging in vivo. The benzene ring and higher HOMO energy have beneficial effect on increasing the lipid radical scavenging activity.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.93mL

0.59mL

0.29mL

14.67mL

2.93mL

1.47mL

29.34mL

5.87mL

2.93mL
参考文献

[1]Friedmann Angeli JP, et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol. 2014 Dec;16(12):1180-91.

[2]Zilka O, et al. On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death. ACS Cent Sci. 2017 Mar 22;3(3):232-243