产品说明书
Sacubitril hemicalcium salt
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同义名 : | 沙卡布曲 钙盐 ;AHU-377 hemicalcium salt;AHU377 (calcium salt);Sacubitril |
| CAS号 : | 1369773-39-6 | |
| 货号 : | A120485 | |
| 分子式 : | C48H56CaN2O10 | |
| 纯度 : | 98% | |
| 分子量 : | 861.044 | |
| MDL号 : | MFCD28137893 | |
| 存储条件： |
粉末 Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 120 mg/mL(139.37 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Sacubitril (AHU-377) is a single-molecule drug composed of the molecular parts of Valsartan (ARB) and Sacubitril hemicalsalt (neprilysin inhibitor) (1:1 ratio). Sacubitril (AHU-377) is converted by enzymatic cleavage of ethyl ester to LBQ657, an active metabolite that inhibits neprilysin [2]. Sacubitril hemicalcium salt is an inactive NEPi precursor, which does not inhibit collagen accumulation in fibroblasts nor cardiac myocyte hypertrophy. However, the active NEPi LBQ657 slightly reduces cardiac myocyte hypertrophy without affecting cardiac fibroblasts[3]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.16mL 0.23mL 0.12mL |
5.81mL 1.16mL 0.58mL |
11.61mL 2.32mL 1.16mL |
| 参考文献 |
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