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Hexylresorcinol

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Chemical Structure| 136-77-6 同义名 : 4-己基苯-1,3-二醇 ;4-Hexylresorcinol;NSC 1570;Ascaryl;Ascarinol;Ascaricid;p-Hexylresorcinol;4-n-Hexylresorcinol
CAS号 : 136-77-6
货号 : A120145
分子式 : C12H18O2
纯度 : 99%+
分子量 : 194.27
MDL号 : MFCD00002284
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(1286.87 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 1 mg/mL(5.15 mM)，配合低频超声助溶

无水乙醇: 100 mg/mL(514.75 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇
动物实验配方：
生物活性
靶点

  • monophenolase

    monophenolase, IC50:1.24 μM

  • diphenolase

    diphenolase, IC50:0.85 μM

  • tyrosinase

    diphenolase, IC50:0.85 μM

    monophenolase, IC50:0.85 μM
描述 4-Hexylbenzene-1,3-Diol is an organic compound with local anaesthetic, antiseptic and anthelmintic properties, is a potent inhibitor of mushroom tyrosinase, causing 90% loss of activity at 100 μM.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.15mL

1.03mL

0.51mL

25.74mL

5.15mL

2.57mL

51.47mL

10.29mL

5.15mL
参考文献

[1]Jo YY, Kweon H, et al. Accelerated biodegradation of silk sutures through matrix metalloproteinase activation by incorporating 4-hexylresorcinol. Sci Rep. 2017 Feb 13;7:42441.

[2]Chen QX, Ke LN, et al. Inhibitory effects of hexylresorcinol and dodecylresorcinol on mushroom (Agaricus bisporus) tyrosinase. Protein J. 2004 Feb;23(2):135-41.