产品说明书
NSC 185058
 |
同义名 : | - |
| CAS号 : | 39122-38-8 | |
| 货号 : | A120064 | |
| 分子式 : | C11H9N3S | |
| 纯度 : | 99%+ | |
| 分子量 : | 215.27 | |
| MDL号 : | MFCD00448857 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,Room temperature 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 120 mg/mL(557.44 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
|
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | NSC 185058 functions as an inhibitor of ATG4B, a prominent cysteine protease. The use of NSC 185058 to inhibit ATG4B significantly reduces autophagic activity [1]. | ||
| 作用机制 | NSC185058 can bind to the pocket containing histidine 280 and aspartic acid 278, which are required for the proteolytic activity of ATG4B, through hydrophilic and hydrophobic binding interactions.[1] | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
4.65mL 0.93mL 0.46mL |
23.23mL 4.65mL 2.32mL |
46.45mL 9.29mL 4.65mL |
| 参考文献 |
|---|