Bevenopran

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Chemical Structure| 676500-67-7 同义名 : CB-5945; ADL-5945; CB-5945, CB5945, CB 5945, ADL-5945, ADL5945, ADL 5945, MK2402, MK 2402, MK-2402,OpRA III
CAS号 : 676500-67-7
货号 : A119986
分子式 : C20H26N4O4
纯度 : 99%
分子量 : 386.44
MDL号 : MFCD26967979
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(310.52 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.59mL

0.52mL

0.26mL

12.94mL

2.59mL

1.29mL

25.88mL

5.18mL

2.59mL
参考文献

[1]Diego L, et al. Novel opioid antagonists for opioid-induced bowel dysfunction. Expert Opin Investig Drugs. 2011 Aug;20(8):1047-56.

[2]Siemens W, et al. Advances in pharmacotherapy for opioid-induced constipation - a systematic review. Expert Opin Pharmacother. 2015 Mar;16(4):515-32.