产品说明书

	同义名 :	-
	CAS号 :	61718-80-7
	货号 :	A119845
	分子式 :	C13H15F3O2
	纯度 :	98%
	分子量 :	260.252
	MDL号 :	MFCD06658173
	存储条件：	粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Fluvoxketone is trifluoromethyl-substituted aryl ketone compound useful as an intermediate in the synthesis of Fluvoxamine, which is a selective serotonin reuptake inhibitor. In the synthesis of Fluvoxamine, the ketone carbonyl of Fluvoxketone is elaborated to an oxime. In vitro，the inhibitory effect of fluvoxamine on actin polymerization was concentration dependent, and its IC50 was approximately 30 μM[3].In vivo，fluvoxamine treated EAE rats showed a decrease in IFN-γ serum levels and an increase in IL-4, pro- and anti-inflammatory cytokines respectively[4].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	3.84mL 0.77mL 0.38mL	19.21mL 3.84mL 1.92mL	38.42mL 7.68mL 3.84mL

参考文献

[1]Altria KD, McLean R. Development and optimisation of a generic micellar electrokinetic capillary chromatography method to support analysis of a wide range of pharmaceuticals and excipients. J Pharm Biomed Anal. 1998 Dec;18(4-5):807-13. [2]Terabe S. Selectivity manipulation in micellar electrokinetic chromatography. J Pharm Biomed Anal. 1992 Oct-Dec;10(10-12):705-15. [3]Hayashi K, Michiue H, Yamada H, Takata K, Nakayama H, Wei FY, Fujimura A, Tazawa H, Asai A, Ogo N, Miyachi H, Nishiki T, Tomizawa K, Takei K, Matsui H. Fluvoxamine, an anti-depressant, inhibits human glioblastoma invasion by disrupting actin polymerization. Sci Rep. 2016 Mar 18;6:23372. doi: 10.1038/srep23372. PMID: 26988603; PMCID: PMC4796892. [4]Pasek RC, Dunn JC, Elsakr JM, Aramandla M, Matta AR, Gannon M. Retraction. Am J Physiol Endocrinol Metab. 2017 Jul 1;313(1):E105. doi: 10.1152/ajpendo.zh1-7764-retr.2017. PMID: 28687703; PMCID: PMC6109701.