INO-1001

产品说明书

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Chemical Structure| 501364-82-5 同义名 : -
CAS号 : 501364-82-5
货号 : A1196009
分子式 : C23H25N3O4S
纯度 : 99%+
分子量 : 439.527
MDL号 : MFCD19443171
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(68.26 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 INO-1001, a potent and selective poly (ADP-ribose) polymerase (PARP) inhibitor, heightens radiation sensitivity and augments radiation-induced cell death by disrupting DNA repair mechanisms, leading to necrotic cell demise[1]. INO-1001 exhibits anti-tumor effects[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.28mL

0.46mL

0.23mL

11.38mL

2.28mL

1.14mL

22.75mL

4.55mL

2.28mL
参考文献

[1]Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17.

[2]Mason KA, et al. INO-1001, a novel inhibitor of poly(ADP-ribose) polymerase, enhances tumor response to doxorubicin. Invest New Drugs. 2008 Feb;26(1):1-5. Epub 2007 Jul 13.