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E6446 2HCl

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Chemical Structure| 1345675-25-3 同义名 : E6446 dihydrochloride
CAS号 : 1345675-25-3
货号 : A119560
分子式 : C27H37Cl2N3O3
纯度 : 99%+
分子量 : 522.507
MDL号 : MFCD29472225
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 6 mg/mL(11.48 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 E6446 dihydrochloride, a powerful and orally active antagonist of TLR7 and TLR9, is utilized in studying harmful inflammatory responses. Additionally, it acts as a potent inhibitor of SCD1 (KD: 4.61 μM), effectively reducing adipogenic differentiation and hepatic lipogenesis via SCD1-ATF3 signaling. E6446 dihydrochloride also ameliorates liver pathology in mice fed a high-fat diet (HFD), suggesting its potential utility in researching non-alcoholic fatty liver disease (NAFLD)[1][2][3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.91mL

0.38mL

0.19mL

9.57mL

1.91mL

0.96mL

19.14mL

3.83mL

1.91mL
参考文献

[1]Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85(3):429-40.

[2]Franklin BS, et al. Therapeutical targeting of nucleic acid-sensing Toll-like receptors prevents experimental cerebral malaria. Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3689-94.

[3]Wang W, et al. Identification of novel SCD1 inhibitor alleviates nonalcoholic fatty liver disease: critical role of liver-adipose axis. Cell Commun Signal. 2023 Sep 30;21(1):268.