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GNF4877

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Chemical Structure| 2041073-22-5 同义名 : -
CAS号 : 2041073-22-5
货号 : A1194998
分子式 : C25H27FN6O4
纯度 : 99%+
分子量 : 494.518
MDL号 : MFCD00078579
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 3 mg/mL(6.07 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 GNF4877 is a highly potent inhibitor of DYRK1A and GSK3β, with IC50 values of 6 nM and 16 nM, respectively. This inhibition results in the prevention of nuclear factor of activated T-cells (NFATc) nuclear export and enhanced β-cell proliferation (with an EC50 of 0.66 μM for mouse β (R7T1) cells) [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.02mL

0.40mL

0.20mL

10.11mL

2.02mL

1.01mL

20.22mL

4.04mL

2.02mL
参考文献

[1]Shen W, et al. Inhibition of DYRK1A and GSK3β induces human β-cell proliferation. Nat Commun. 2015 Oct 26;6:8372.