产品说明书
CG347B
 |
同义名 : | - |
| CAS号 : | 1598426-03-9 | |
| 货号 : | A1193427 | |
| 分子式 : | C16H17N3O2 | |
| 纯度 : | 99%+ | |
| 分子量 : | 283.325 | |
| MDL号 : | MFCD28347705 | |
| 存储条件： |
粉末 Keep in dark place,Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 250 mg/mL(882.38 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Histone deacetylases (HDAC) are responsible for the deacetylation of lysine residues on both histone and non-histone proteins. HDAC6 belongs to class IIB HDAC. HDAC6 inhibitors are expected to possess therapeutic potential in oncology, immunology, and neurology. CG347B is a selective HDAC6 inhibitor, which also involves I synthesis of other metalloenzyne inhibitors[1]. In NCI-H460/CDDP cells, treatment with CG347B did not significantly alter the expression of high temperature requirement factor serine peptidase 1 at either mRNA or protein levels[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
3.53mL 0.71mL 0.35mL |
17.65mL 3.53mL 1.76mL |
35.30mL 7.06mL 3.53mL |
| 参考文献 |
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[1]Christopher M. Yates. Metalloenzyme inhibitor compounds. Google Patnets. 2018. |