产品说明书

Anthracene-9-carboxylic acid

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Chemical Structure| 723-62-6 同义名 : 9-Anthracenecarboxylic acid;9-AC;NSC 151909;9-Carboxyanthracene;9-Anthroic Acid
CAS号 : 723-62-6
货号 : A119156
分子式 : C15H10O2
纯度 : 98%
分子量 : 222.239
MDL号 : MFCD00001257
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(539.96 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Anthracene-9-carboxylic acid is an anthracene derivative traditionally used to block and identify Ca2+-activated Cl- currents (CaCC) in various cell types, such as different smooth muscle cells, epithelial cells, and salivary gland cells. In HEK 293T cells, Anthracene-9-carboxylic acid induces voltage-dependent block of outward currents and inhibits a larger proportion of the current with increasing depolarization. Following depolarizing voltage, Anthracene-9-carboxylic Acid causes a marked enhancement of the tail current at -100 mV and prolongs the inactivation kinetics in HEK 293T cells[1]. Anthracene-9-carboxylic acid, at concentration of 500 μM, produces a modest inhibition of the maximal outward Cl- current at +70 mV (21±10%), but enhances the amplitude of the instantaneous inward relaxation at -80 mV by 321±34%, in rabbit pulmonary artery smooth muscle cells[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.50mL

0.90mL

0.45mL

22.50mL

4.50mL

2.25mL

45.00mL

9.00mL

4.50mL
参考文献

[1]Cherian OL, Menini A, Boccaccio A. Multiple effects of anthracene-9-carboxylic acid on the TMEM16B/anoctamin2 calcium-activated chloride channel. Biochim Biophys Acta. 2015 Apr;1848(4):1005-13.

[2]Piper AS, Greenwood IA. Anomalous effect of anthracene-9-carboxylic acid on calcium-activated chloride currents in rabbit pulmonary artery smooth muscle cells. Br J Pharmacol. 2003 Jan;138(1):31-8.