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Tyrphostin AG30

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Chemical Structure| 122520-79-0 同义名 : AG30
CAS号 : 122520-79-0
货号 : A1188508
分子式 : C10H7NO4
纯度 : 99%+
分子量 : 205.167
MDL号 : MFCD09739079
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(584.89 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • EGFR/ErbB1
描述 Tyrphostin AG30 (AG30) is a potent and selective EGFR tyrosine kinase inhibitor. The c-ErbB-specific tyrphostin AG30 specifically blocked STAT5 activation, implicating this signal transducer in c-ErbB-induced self renewal[1]. Treatment of human colon cancer cell lines, LS 174T, COLO 205, and SW620, with sodium butyrate and 8-Cl-cAMP or tyrphostins AG-30 and AG-34, significantly attenuated TPK (tyrosine protein kinase) activity concomitantly with an increase in the activity of alkaline phosphatase, an enzymatic marker of intestinal cell differentiation. The induction of the differentiated phenotype in colon cancer cells is associated with a marked decrease in TPK activity and tyrosine phosphorylation[2]. Preincubation of B lymphocytes with two different tyrphostins blocked anti-IgM-induced tyrosine phosphorylation and actin polymerization[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.87mL

0.97mL

0.49mL

24.37mL

4.87mL

2.44mL

48.74mL

9.75mL

4.87mL
参考文献

[1]Wessely O, Mellitzer G, von Lindern M, et al. Distinct roles of the receptor tyrosine kinases c-ErbB and c-Kit in regulating the balance between erythroid cell proliferation and differentiation. Cell Growth Differ. 1997;8(5):481-493

[2]Schwartz B, Lamprecht SA, Polak-Charcon S, Niv Y, Kim YS. Induction of the differentiated phenotype in human colon cancer cell is associated with the attenuation of subcellular tyrosine phosphorylation. Oncol Res. 1995;7(6):277-287

[3]Melamed I, Downey GP, Roifman CM. Tyrosine phosphorylation is essential for microfilament assembly in B lymphocytes. Biochem Biophys Res Commun. 1991;176(3):1424-1429