产品说明书
TCS PIM-1 1
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同义名 : | SC 204330;Pim-1 Kinase Inhibitor II |
| CAS号 : | 491871-58-0 | |
| 货号 : | A118376 | |
| 分子式 : | C18H11BrN2O2 | |
| 纯度 : | 99%+ | |
| 分子量 : | 367.196 | |
| MDL号 : | MFCD00276275 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,Room temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(285.95 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
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| 描述 | Pim (provirus integration site for Moloney murine leukemia virus) family proteins are highly conserved serine/threonine kinases implicated in transcription, translation, cell cycle, survival, and drug resistance through the numerous targets. TCS PIM-1 1 is a Pim-1 inhibitor with IC50 value of 50nM (measured by Pim-1 kinase activity), lacking in vitro inhibitory activity toward related kinase Pim-2 and MEK1/2 (IC50 > 20μM)[1]. | ||
| 作用机制 | TCS PIM-1 1 can bound within the ATP-binding site of Pim-1, suggesting it as an ATP-competitive inhibitor.[1] | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.72mL 0.54mL 0.27mL |
13.62mL 2.72mL 1.36mL |
27.23mL 5.45mL 2.72mL |
| 参考文献 |
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