MRT-83

产品说明书

Print
Chemical Structure| 1263131-92-5 同义名 : -
CAS号 : 1263131-92-5
货号 : A1177303
分子式 : C31H30N4O5
纯度 : 98%
分子量 : 538.594
MDL号 : MFCD25977098
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(464.17 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 MRT-83 demonstrates potent antagonist activity against the Sonic Hedgehog (Shh) signaling pathway, with an IC50 of approximately 3 nM in inhibiting ShhN-induced proliferation of rat granule cell precursors (GCPs). It also effectively blocks SAG-induced GCP proliferation and BODIPY-cyclopamine (BC) binding to both human and mouse Smoothened (Smo) receptors in cell-based assays, underscoring its efficacy in disrupting Shh-mediated cellular responses[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.86mL

0.37mL

0.19mL

9.28mL

1.86mL

0.93mL

18.57mL

3.71mL

1.86mL
参考文献

[1]Roudaut H, et al. Identification and mechanism of action of the acylguanidine MRT-83, a novel potent Smoothened antagonist. Mol Pharmacol. 2011 Mar;79(3):453-60.