产品说明书

SB 204990

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Chemical Structure| 154566-12-8 同义名 : -
CAS号 : 154566-12-8
货号 : A1177275
分子式 : C18H22Cl2O5
纯度 : 99%+
分子量 : 389.27
MDL号 : MFCD28127018
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(269.74 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 25 mg/mL(64.22 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 SB204990 (SB) is a specific inhibitor of the ATP-citrate lyase (ACLY) enzyme, leading to a reduction in cytosolic Ac-CoA levels and consequently expected to diminish levels of acetylated and active β-catenin[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.57mL

0.51mL

0.26mL

12.84mL

2.57mL

1.28mL

25.69mL

5.14mL

2.57mL
参考文献

[1]Shares BH, et al. Active mitochondria support osteogenic differentiation by stimulating β-catenin acetylation. J Biol Chem. 2018 Oct 12;293(41):16019-16027.

[2]Pearce NJ, et al. The role of ATP citrate-lyase in the metabolic regulation of plasma lipids. Hypolipidaemic effects of SB-204990, a lactone prodrug of the potent ATP citrate-lyase inhibitor SB-201076. Biochem J. 1998 Aug 15;334 ( Pt 1):113-9.