AM211

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Chemical Structure| 1175526-27-8 同义名 : AM211 free acid
CAS号 : 1175526-27-8
货号 : A1177231
分子式 : C27H27F3N2O4
纯度 : 99%+
分子量 : 500.51
MDL号 : MFCD22124468
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(239.76 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 AM211 is a potent, selective, and orally bioavailable antagonist of prostaglandin D2 (PGD2) receptor type 2 (DP2). It exhibits IC50 values of 4.9 nM, 7.8 nM, 4.9 nM, and 10.4 nM for human, mouse, guinea pig, and rat DP2, respectively. In the presence of 0.2% serum albumin, AM211 inhibits radiolabeled PGD2 binding to human, mouse, guinea pig, and rat DP2 with IC50 values of 12.2 nM, 20.1 nM, 22.9 nM, and 34.2 nM, respectively. AM211 demonstrates high selectivity for DP2 over other receptors in the prostanoid family, with IC50 values for the inhibition of radioligand binding to human TP, IP, DP1, and FP receptors exceeding 100 μM. AM211 (100 μM) exhibits no activity against COX-1, COX-2 enzymes, as well as the PPAR family of nuclear receptors[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.00mL

0.40mL

0.20mL

9.99mL

2.00mL

1.00mL

19.98mL

4.00mL

2.00mL
参考文献

[1]Bain G, et al. Pharmacology of AM211, a potent and selective prostaglandin D2 receptor type 2 antagonist that is active in animal models of allergic inflammation. J Pharmacol Exp Ther. 2011 Jul;338(1):290-301.