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KPLH1130

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Chemical Structure| 906669-07-6 同义名 : -
CAS号 : 906669-07-6
货号 : A1177202
分子式 : C15H13N3O3
纯度 : 98%
分子量 : 283.282
MDL号 : MFCD32067959
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 130 mg/mL(458.91 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 KPLH1130 is a selective inhibitor of pyruvate dehydrogenase kinase (PDK), which inhibits macrophage polarization and reduces proinflammatory reactions. Furthermore, KPLH1130 enhances glucose tolerance in mice fed with a high-fat diet (HFD)[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.53mL

0.71mL

0.35mL

17.65mL

3.53mL

1.77mL

35.30mL

7.06mL

3.53mL
参考文献

[1]Min BK, et al. Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint for Polarization of Macrophages to the M1 Phenotype. Front Immunol. 2019 May 7;10:944.