PQM130

产品说明书

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Chemical Structure| 2089415-51-8 同义名 : -
CAS号 : 2089415-51-8
货号 : A1177183
分子式 : C23H27NO4
纯度 : 99%+
分子量 : 381.465
MDL号 : -
存储条件:

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 1.5 mg/mL(3.93 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 PQM130, a Feruloyl-Donepezil brain injury hybrid, is a multi-target drug candidate that fights neurotoxicity caused by Aβ1-42 oligomers (AβO) and has anti-inflammatory activity. PQM130 is a neuroprotective compound developed as an anti-AD drug[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.62mL

0.52mL

0.26mL

13.11mL

2.62mL

1.31mL

26.21mL

5.24mL

2.62mL

参考文献

[1]Morroni F, et al. PQM130, a Novel Feruloyl-Donepezil Hybrid Compound, Effectively Ameliorates the Cognitive Impairments and Pathology in a Mouse Model of Alzheimer's Disease. Front Pharmacol. 2019 Jun 12;10:658.