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PFE-360

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Chemical Structure| 1527475-61-1 同义名 : PF-06685360
CAS号 : 1527475-61-1
货号 : A1177088
分子式 : C16H16N6O
纯度 : 98%
分子量 : 308.338
MDL号 : MFCD31697701
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 9 mg/mL(29.19 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 PFE-360 , also known as PF-06685360, is a potent, selective, brain-penetrating and orally active LRRK2 inhibitor with an in vivo mean IC50 value of 2.3 nM[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.24mL

0.65mL

0.32mL

16.22mL

3.24mL

1.62mL

32.43mL

6.49mL

3.24mL
参考文献

[1]Marco A.S. Baptista, et al. LRRK2 Kinase Inhibitors of Different Structural Classes Induce Abnormal Accumulation of Lamellar Bodies in Type II Pneumocytes in Non-Human Primates but are Reversible and Without Pulmonary Functional Consequences.

[2]Andersen MA, et al. Parkinson's disease-like burst firing activity in subthalamic nucleus induced by AAV-α-synuclein is normalized by LRRK2 modulation. Neurobiol Dis. 2018 Aug;116:13-27.